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1.
Oral Health Prev Dent ; 14(2): 117-23, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26525123

RESUMO

PURPOSE: To assess the oral health-related quality of life of the Israeli elderly. MATERIALS AND METHODS: Data were collected from a subsample of those interviewed for the cross-sectional Mabat Zahav National Health and Nutrition Survey of the Elderly, carried out in 2005 and 2006 by the Ministry of Health in Israel. In-person interviews were conducted in the interviewees' homes using a structured questionnaire which included 7 questions on subjective dental health status and the 14 questions of the Oral Health Impact Profile 14 (OHIP-14). Statistical significance of continuous variables was assessed with the Student t-test; categorical variables with normal distribution were analysed using the chi-square test and those with non-normal distribution with the Wilcoxon Mann-Whitney two-sample test. RESULTS: 828 Jews and 159 Arabs from the total survey population of 1852 elderly (1536 Jews and 316 Arabs) completed the OHIP-14 questionnaire. An impact of oral health on the quality of life was reported by 16.6% of the respondents, 19.2% of females and 13.9% of males (p<0.05). There were statistically significant differences in impact prevalence by gender, place of birth and economic status. No such differences were found by age group, population group or education. Significant statistical correlation was found between subjective assessment of general and dental health and OHIP impact prevalence, with poorer assessment correlated with increased prevalence of impact. CONCLUSIONS: The quality of life of 17% of Israeli elderly is affected by oral health. The OHIP-14 findings emphasise the importance of including basic dental treatment (treatment of dental pain and infections) in the range of services covered by the National Health Insurance Law.


Assuntos
Saúde Bucal , Qualidade de Vida , Idoso , Idoso de 80 Anos ou mais , Árabes , Estudos Transversais , Pessoas com Deficiência/psicologia , Escolaridade , Feminino , Nível de Saúde , Humanos , Israel , Judeus/etnologia , Masculino , Inquéritos Nutricionais , Dor/psicologia , Características de Residência , Fatores Sexuais , Classe Social , Estresse Psicológico/psicologia
2.
Women Health ; 56(1): 78-97, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26214539

RESUMO

The current investigation aimed to assess levels of knowledge about risk factors for heart disease among midlife Israeli women, and to evaluate the relationship of knowledge to personal risk factors and vulnerability to heart disease. Face-to-face interviews with women aged 45-64 years were conducted during 2004-2006 within three population groups: long-term Jewish residents (LTR), immigrants from the former Soviet Union, and Arab women. The survey instrument included six knowledge statements relating to: the risk after menopause, family history, elevated cholesterol level, diabetes, obesity, and warning signs of a heart attack. The findings showed wide disparities in knowledge by educational level and between immigrants and LTR, after taking into account personal risk factors and education. Personal risk factors were not significantly related to the knowledge items, except for personal history of cardiovascular disease, which was associated with knowledge about "warning signs of a heart attack" and "family history." Women who perceived themselves as more vulnerable to heart disease were more likely to identify several risk factors correctly. These findings stress the need to increase knowledge about heart disease, especially among less educated and minority women, and to emphasize the risk of patients' personal status by health providers.


Assuntos
Emigrantes e Imigrantes/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Cardiopatias/etnologia , Pós-Menopausa/etnologia , Saúde da Mulher/etnologia , Árabes/etnologia , Feminino , Nível de Saúde , Humanos , Entrevistas como Assunto , Israel/epidemiologia , Israel/etnologia , Judeus/etnologia , Menopausa/etnologia , Pessoa de Meia-Idade , Pós-Menopausa/psicologia , Pesquisa Qualitativa , Fatores de Risco , Fatores Socioeconômicos , Inquéritos e Questionários , U.R.S.S./etnologia
3.
Medicine (Baltimore) ; 94(18): e673, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25950682

RESUMO

Infliximab is an anti-tumor necrosis factor (TNF) used for treatment of inflammatory bowel disease (IBD) as well as rheumatoid arthritis, psoriasis, and other inflammatory conditions. Antibodies to infliximab (ATI) develop in approximately 45% of infliximab-treated IBD patients and are correlated with loss of clinical response. Scarce data exist as to factors which predict infliximab immunogenicity.To investigate factors that may predict formation of antibodies to infliximab (ATI) and infliximab therapy failure an observational study of consecutive IBD patients treated with infliximab between 2009 and 2013 was performed. Trough levels of ATI were measured. Patients were monitored for disease activity using clinical activity indexes and were classified according to ATI formation and clinical response. All clinical and demographic parameters were analyzed for association with the designated outcomes.One hundred fifty-nine patients were included and 1505 sera were tested. On multivariate analysis, Jewish Ashkenazi ethnicity was protective against both development of ATI (odds ratio [OR] 0.35, 95% confidence interval [CI] 0.17-0.7, P = 0.005) and treatment failure (OR 0.29, 95% CI 0.13-0.66, P = 0.003). Concomitant immunomodulator therapy was also negatively associated with immunogenicity and infliximab therapy failure (OR 0.31, 95% CI 0.15-0.65, P = 0.002; OR 0.42 95% CI 0.18-0.99, p = 0.04, respectively), whereas episodic therapy was positively associated with both outcomes (OR 4.2 95% CI 1.07-16.1, p = 0.04, OR 4.45 95% CI 1.2-16.6, p = 0.026 respectively). All other variables, including IBD type, gender, weight, age, smoking status and disease duration, were not predictive of ATI formation or clinical failure. However, among Crohn's disease patients, a non-stricturing non-penetrating phenotype was protective against ATI formation (OR 0.4, 95% CI 0.14-0.96, p = 0.04). P = 0.04, respectively), whereas episodic/interrupted therapy was positively associated with both outcomes (OR 4.2, 95% CI 1.07-16.1, P = 0.04; OR 4.45, 95% CI 1.2-16.6, P = 0.026, respectively). All other variables, including IBD type, sex, weight, age, smoking status, and disease duration, were not predictive of ATI formation or clinical failure. However, among Crohn disease patients, a nonstricturing nonpenetrating phenotype was protective against ATI formation (OR 0.4, 95% CI 0.14-0.96, P = 0.04).Jewish Ashkenazi ethnicity is protective of ATI formation and infliximab therapy failure. These findings suggest a role for ethnicity, and implicitly for genetic predisposition, in modulating the risk of anti-TNF immunogenicity and treatment unresponsiveness.


Assuntos
Anti-Inflamatórios não Esteroides/imunologia , Anticorpos Monoclonais/imunologia , Anticorpos/sangue , Doenças Inflamatórias Intestinais/tratamento farmacológico , Judeus/etnologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anti-Inflamatórios não Esteroides/uso terapêutico , Anticorpos Monoclonais/uso terapêutico , Biomarcadores/sangue , Feminino , Seguimentos , Humanos , Doenças Inflamatórias Intestinais/etnologia , Doenças Inflamatórias Intestinais/imunologia , Infliximab , Estimativa de Kaplan-Meier , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estudos Retrospectivos , Falha de Tratamento , Adulto Jovem
4.
Midwifery ; 31(6): 625-32, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25840622

RESUMO

BACKGROUND: childbirth is a positive experience for most women yet some women express distress after birth. Traumatic experience can sometimes cause post-traumatic stress disorder (PTSD) in relation to childbirth. Prevalence of traumatic birth experience and PTSD after childbirth differs between cultures. OBJECTIVES: to examine the subjective recall of childbirth experiences and PTSD symptoms of Israeli Jewish and Arab women; to examine comparatively the prevalence of PTSD symptoms six to eight weeks after childbirth and to establish the factors that predict PTSD symptoms. METHODS: a prospective study was conducted in a region characterised by wide variations in ethnocultural groups. The study was comprised of two time points: Time 1 (T1) interviews were conducted at the bedside of the women in the maternity ward of each hospital 24-48 hours after childbirth. Time 2 (T2), all 171 women participating in T1 were interviewed by phone six to eight weeks after childbirth. FINDINGS: 34 women (19.9%) reported their labour as traumatic 24-48 hours after birth (T1), and six to eight weeks later (T2) 67 women (39.2%) assessed their experience as traumatic. More Arab women (69.6%) than Jewish women (56.5%) had a positive memory of childbirth, but this difference only approached statistical significance (p=.09). Results showed rather low frequencies of PTSD symptoms, and no ethnic difference. PTSD symptoms were significantly and positively predicted by subjective recollection of childbirth experience (Time 2). PTSD symptoms were higher for women who did not have a vaginal birth, and more women with PTSD symptoms were not breast feeding. CONCLUSIONS: we found more similarities than differences between Arab and Jewish women׳s experience of their births and no differences between them on the prevalence of PTSD symptoms after birth. The results suggest that non-vaginal birth (instrumental or caesarean section) and negative recollection of the childbirth experience are important factors related to the development of PTSD symptoms after birth, and that women with PTSD symptoms are less likely to breast feed.


Assuntos
Acontecimentos que Mudam a Vida , Parto/psicologia , Transtornos de Estresse Pós-Traumáticos/etiologia , Adolescente , Adulto , Ansiedade/epidemiologia , Ansiedade/etiologia , Árabes/etnologia , Árabes/psicologia , Estudos Transversais , Depressão/epidemiologia , Depressão/etiologia , Feminino , Humanos , Israel/epidemiologia , Judeus/etnologia , Judeus/psicologia , Gravidez , Estudos Prospectivos , Transtornos de Estresse Pós-Traumáticos/epidemiologia
5.
Addict Behav ; 46: 31-8, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25777746

RESUMO

Experiencing stress and exposure to terrorism may have an adverse effect on health risk behaviors. Few studies have examined alcohol use among adults living in Israel under chronic, stressful terrorism-related conditions. In this study, we examined the relationships of demographics, past stressful events, and terrorism exposure to the frequency of alcohol use and the mediating roles of depressive and post-traumatic stress disorder (PTSD) symptoms. We used three waves of data from a 2007-2008 nationally representative sample of Jewish and Palestinian adults in Israel. We assessed past stressful events, in addition to direct and indirect exposures to terrorism. Results indicated that past stressful events and exposure to terrorism were not directly associated with alcohol use, but were indirectly associated and mediated by depressive and PTSD symptomology. Mental health symptoms were differentially associated with alcohol use. More frequent drinking was mediated by higher levels of depression, including for women and Palestinians; however, PTSD symptom severity was related to less frequent drinking. Mental health may play a prominent role in the frequency of alcohol use among adults exposed to terrorism in Israel. Alcohol use, as a coping mechanism, may differ by demographic characteristics (gender and ethnicity) and psychological symptomology for adults living in a conflict zone in Israel.


Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Árabes/psicologia , Conflitos Armados/psicologia , Judeus/psicologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Árabes/etnologia , Transtorno Depressivo/etnologia , Transtorno Depressivo/psicologia , Feminino , Humanos , Israel/etnologia , Judeus/etnologia , Masculino , Pessoa de Meia-Idade , Transtornos de Estresse Pós-Traumáticos/etnologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Exposição à Guerra , Adulto Jovem
6.
J Clin Gastroenterol ; 49(4): 300-5, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24637731

RESUMO

BACKGROUND: The prevalence of irritable bowel syndrome (IBS) in the community has been reported in numerous cross-sectional surveys. However, little is known about the incidence and predictive factors for the clinical diagnosis of IBS. METHODS: We examined the association of socioeconomic, anthropometric, and occupational factors with the incidence of IBS in a cohort of 440,822 young Israeli adults aged 18 to 39 who served in active military service during the years 2005 to 2011. RESULTS: During the follow-up of 1,925,003 person-years, IBS was diagnosed de novo in 976 patients, giving an incidence rate of 221:100,000 (0.2%) person-years for the diagnosis of IBS. On multivariable Cox analysis, higher socioeconomic status [hazard ratio (HR) 1.629; 95% confidence interval (CI), 1.328-1.999; P<0.0001], Israeli birth (HR 1.362; 95% CI, 1.084-1.712; P=0.008), Jewish ethnicity (HR 2.089; 95% CI, 1.344-3.248; P=0.001), education ≥than 11 years (HR 1.674; 95% CI, 1.019-2.751; P=0.042), and a noncombat military position (HR 1.196; 95% CI, 1.024-1.397; P=0.024) were found to be risk factors for the diagnosis or for the worsening of IBS. Overweight (HR 0.744; 95% CI, 0.589-0.941; P=0.014), obesity (HR 0.698; 95% CI, 0.510-0.95; P=0.025), living in a rural settlement (HR 0.705; 95% CI, 0.561-0.886; P=0.003), and Middle Eastern (HR 0.739; 95% CI, 0.617-0.884; P=0.001,) or North African and Ethiopian origin (HR 0.702; 95% CI, 0.585-0.842; P<0.001) were found to be protective for the diagnosis or the worsening of IBS. CONCLUSIONS: This study provides novel data on the socioeconomic, anthropometric, and occupational factors predictive for IBS development. The predictive factors for IBS diagnosis may point to the fact that stress had a lower impact on IBS incidence in our study cohort.


Assuntos
Índice de Massa Corporal , Síndrome do Intestino Irritável/epidemiologia , Ocupações/estatística & dados numéricos , Fatores Socioeconômicos , Adolescente , Adulto , África do Norte/etnologia , Estudos de Coortes , Escolaridade , Etiópia/etnologia , Feminino , Humanos , Incidência , Israel/epidemiologia , Judeus/etnologia , Masculino , Oriente Médio/etnologia , Militares/estatística & dados numéricos , Sobrepeso/epidemiologia , Fatores de Risco , População Rural/estatística & dados numéricos , Adulto Jovem
7.
Child Abuse Negl ; 41: 136-45, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25220482

RESUMO

This study expands research on the relationship between community (defined here as a locality) characteristics and child maltreatment. Research in this field is not new, but it is scarce. Our study is unique by examining changes between two periods rather than focusing on one point in time. Furthermore, our study examines structural conditions in small and medium size localities in Israel, a non-Western and non-Christian society. We compare our results with those from studies on inner-city and suburban neighborhoods in Western countries and earlier studies in Israel. We collected data on 169 Israeli localities, ranging from small ones (with as few as 1,500 residents) to medium size localities (i.e., towns) (with as many as 50,000 residents) in which approximately 34% of the Israeli child population resides. Our study tested four hypotheses: (1) Socioeconomic characteristics of the locality will be negatively correlated with the availability of social services; (2) Reported child maltreatment rates will be negatively correlated with the socioeconomic characteristics of the locality; (3) The availability of social services will be positively correlated with reported child maltreatment rates; and (4) Overall reported child maltreatment rates will be negatively correlated with the overall status of the localities. We have supported our second and third hypothesis in full, and partially supported our first and fourth hypothesis. In particular we have demonstrated that while demographics play a different role in Israel than in other countries in regard to child maltreatment, social, economic and cultural context are crucial for understating reported rates of child maltreatment.


Assuntos
Maus-Tratos Infantis/estatística & dados numéricos , Características de Residência/estatística & dados numéricos , Apoio Social , Adolescente , Distribuição por Idade , Árabes/etnologia , Criança , Maus-Tratos Infantis/etnologia , Pré-Escolar , Características da Família , Humanos , Lactente , Recém-Nascido , Israel/etnologia , Judeus/etnologia , Notificação de Abuso , Alocação de Recursos/estatística & dados numéricos , Classe Social , Seguridade Social/estatística & dados numéricos
8.
J Pain Symptom Manage ; 49(5): 871-7, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25462209

RESUMO

CONTEXT: There is a dearth of studies on how cultural background influences patients' attitudes and choices regarding complementary and traditional medicine (CTM) integration. OBJECTIVES: To explore Arab and Jewish patients' perspectives regarding CTM use and its possible integration within conventional cancer care. METHODS: This was a cross-cultural study. We developed a 27-item questionnaire that evaluates patients' perceptions regarding CTM integration in supportive cancer care. The questionnaire was administered to a convenience sample of patients receiving cancer care in community and hospital oncology centers. RESULTS: Of the 770 respondents (response rate 88%), 324 defined their religion as Muslim, Christian, or Druze (henceforth, regarded as Arabs) and 446 were Jews. Respondents in the two groups differed significantly in terms of age, gender, marital status, number of children, education, religiosity, and prevalence of cancer types (excluding breast cancer). Although Arab respondents reported less use of CTM for cancer-related outcomes (39.6% vs. 52.1%; P = 0.001), they expressed greater support than Jewish respondents for optional CTM consultation if provided within conventional oncology care (P < 0.0001). Respondents in both groups stated that their primary expectation from the oncologist concerning CTM was to participate in formulating a CTM treatment plan to be provided within the oncology department. Compared with Arab respondents, Jews expected CTM consultations to focus on improving daily functioning and coping, reducing chemotherapy side effects, and providing spiritual support. CONCLUSION: Although quality of life-related expectations are more pronounced among Jewish respondents, both groups share the expectation from their health care providers to be actively involved in construction of a tailored integrative CTM treatment plan.


Assuntos
Árabes/estatística & dados numéricos , Terapias Complementares/estatística & dados numéricos , Comparação Transcultural , Judeus/estatística & dados numéricos , Neoplasias/etnologia , Neoplasias/terapia , Árabes/etnologia , Atitude Frente a Saúde/etnologia , Terapia Combinada/estatística & dados numéricos , Assistência à Saúde Culturalmente Competente , Feminino , Humanos , Israel/etnologia , Judeus/etnologia , Masculino , Pessoa de Meia-Idade , Cuidados Paliativos/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/etnologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Integração de Sistemas
9.
JAMA Neurol ; 71(12): 1567-72, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25347348

RESUMO

IMPORTANCE: Genetic diseases often cluster in different ethnic groups and may present with recognizable unique clinical manifestations. OBJECTIVE: To summarize current knowledge about movement disorders overrepresented among patients of Jewish ancestry. EVIDENCE REVIEW: We searched PubMed and the OMIM and Israeli National Genetic Databases for articles published from 1969 through March 31, 2014, using the search terms Parkinson's disease,movement disorders, ataxia, dystonia, chorea, and Creutzfeldt-Jakob with and Jewish. The final reference list was generated by giving priority to articles directly related to the topic, articles with the latest information, and comprehensive but relevant reviews. FINDINGS: About one-third of patients with sporadic Parkinson disease (PD) and more than 40% of patients with familial PD of Ashkenazi Jewish descent likely carry the G2019S mutation in the LRRK2 gene, a mutation in the glucocerebrosidase (GBA) gene, or both. This finding contrasts with only a 10% frequency of these mutations in patients with PD who are of non-Jewish ancestry. A dystonia due to a TOR1A gene mutation is responsible for most early-onset autosomal dominant dystonia, and 90% of Ashkenazi Jews who develop early-onset disease have TOR1A-related dystonia. Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomatosis tend to cluster among Jews of North African descent, and Machado-Joseph disease is particularly frequent in Yemenite Jews. CONCLUSIONS AND RELEVANCE: Genetic forms of PD are much more common in patients of Ashkenazi Jewish ancestry with sporadic and familial PD than in the non-Jewish population. The recognition of the particular movement disorder phenotype, coupled with information about the ethnic origin of the patients, may point to specific genetic testing and lead to early and correct diagnosis.


Assuntos
Judeus/genética , Transtornos dos Movimentos/genética , Doença de Parkinson/genética , Humanos , Judeus/etnologia , Transtornos dos Movimentos/etnologia , Doença de Parkinson/etnologia
12.
J Nurs Manag ; 22(4): 499-505, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24809240

RESUMO

AIM: To examine the association between perceived organisational values and organisational commitment among Israeli nurses in relation to their ethno-cultural background. BACKGROUND: Differences and the discrepancy between individuals' organisational values and those of their organisational culture are a potential source of adjustment difficulties. Organisational values are considered to be the bond of the individual to their organisation. In multicultural societies, such as Israel, the differences in perception of organisational values and organisational commitment may be reflected within workgroups. METHOD: Data were collected using a questionnaire among 106 hospital nurses. About 59.8% of the sample were Israeli-born. RESULTS: A positive correlation was found between organisational values and organisational commitment. Significant differences were found in organisational values and organisational commitment between Israeli-born-, USSR-born- and Ethiopian-born nurses. The socio-demographic profile modified the effect of organisational values on organisational commitment: when the nurse was male, Muslim, religiously orthodox and without academic education, the effect of organisational values on organisational commitment was higher. CONCLUSION: Findings confirm the role of culture and ethnicity in the perception of organisational values and the level of organisational commitment among nurses. IMPLICATIONS FOR NURSING MANAGEMENT: Assessing ethno-cultural differences in organisational values and organisational commitment provides a fuller understanding of nurses' ability to adjust to their work environment and helps nurse managers devise means to increase nurses' commitment.


Assuntos
Recursos Humanos de Enfermagem no Hospital/psicologia , Cultura Organizacional , Lealdade ao Trabalho , Valores Sociais/etnologia , Adulto , Árabes/etnologia , Árabes/psicologia , Comparação Transcultural , Estudos Transversais , Diversidade Cultural , Etiópia/etnologia , Feminino , Humanos , Islamismo/psicologia , Israel , Judeus/etnologia , Judeus/psicologia , Masculino , Inquéritos e Questionários , U.R.S.S./etnologia
13.
Drug Metabol Drug Interact ; 29(4): 221-33, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24867283

RESUMO

Spanning over 2000 years, the Jewish population has a long history of migration, population bottlenecks, expansions, and geographical isolation, which has resulted in a unique genetic architecture among the Jewish people. As such, many Mendelian disease genes and founder mutations for autosomal recessive diseases have been discovered in several Jewish groups, which have prompted recent genomic studies in the Jewish population on common disease susceptibility and other complex traits. Although few studies on the genetic determinants of drug response variability have been reported in the Jewish population, a number of unique pharmacogenetic variants have been discovered that are more common in Jewish populations than in other major racial groups. Notable examples identified in the Ashkenazi Jewish (AJ) population include the vitamin K epoxide reductase complex subunit 1 (VKORC1) c.106G>T (p.D36Y) variant associated with high warfarin dosing requirements and the recently reported cytochrome P450 2C19 (CYP2C19) allele, CYP2C19*4B, that harbors both loss-of-function [*4 (c.1A>G)] and increased-function [*17 (c.-806C>T)] variants on the same haplotype. These data are encouraging in that like other ethnicities and subpopulations, the Jewish population likely harbors numerous pharmacogenetic variants that are uncommon or absent in other larger racial groups and ethnicities. In addition to unique variants, common multi-ethnic variants in key drug metabolism genes (e.g., ABCB1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, NAT2) have also been detected in the AJ and other Jewish groups. This review aims to summarize the currently available pharmacogenetics literature and discuss future directions for related research with this unique population.


Assuntos
Sistema Enzimático do Citocromo P-450/genética , Judeus/genética , Farmacogenética/métodos , Vigilância da População , Sistema Enzimático do Citocromo P-450/metabolismo , Humanos , Judeus/etnologia , Preparações Farmacêuticas/administração & dosagem , Preparações Farmacêuticas/metabolismo , Farmacogenética/tendências , Vigilância da População/métodos
14.
Invest Ophthalmol Vis Sci ; 55(2): 1149-60, 2014 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-24474277

RESUMO

PURPOSE: The Israeli and Palestinian populations are known to have a relatively high level of consanguineous marriages, leading to a relatively high frequency of autosomal recessive (AR) diseases. Our purpose was to use the homozygosity mapping approach, aiming to prioritize the set of genes and identify the molecular genetic causes underlying AR retinal degenerations in the Israeli and Palestinian populations. METHODS: Clinical analysis included family history, ocular examination, full-field electroretinography (ERG), and funduscopy. Molecular analysis included homozygosity mapping and mutation analysis of candidate genes. RESULTS: We recruited for the study families with AR nonsyndromic retinal degenerations, including mainly retinitis pigmentosa (RP), cone-rod degeneration (CRD), and Leber congenital amaurosis (LCA). With the aim to identify the causative genes in these families, we performed homozygosity mapping using whole genome single nucleotide polymorphism (SNP) arrays in 125 families. The analysis revealed the identification of 14 mutations, 5 of which are novel, in 16 of the families. The mutations were identified in the following eight genes: RDH12, PROM1, MFRP, TULP1, LCA5, CEP290, NR2E3, and EYS. While most patients had a retinal disease that is compatible with the causing gene, in some cases new clinical features are evident. CONCLUSIONS: Homozygosity mapping is a powerful tool to identify genetic defects underlying heterogeneous AR disorders, such as RP and LCA, in consanguineous and nonconsanguineous patients. The identification of significant and large homozygous regions, which do not include any known retinal disease genes, may be a useful tool to identify novel disease-causing genes, using next generation sequencing.


Assuntos
Análise Mutacional de DNA , Proteínas do Olho/genética , Predisposição Genética para Doença , Mutação , Polimorfismo de Nucleotídeo Único , Degeneração Retiniana/genética , Retinite Pigmentosa/genética , Árabes/etnologia , Mapeamento Cromossômico , Consanguinidade , Eletrorretinografia , Feminino , Ligação Genética , Homozigoto , Humanos , Israel/epidemiologia , Judeus/etnologia , Masculino , Linhagem , Degeneração Retiniana/etnologia , Retinite Pigmentosa/etnologia
15.
J Am Geriatr Soc ; 62(1): 153-8, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24383816

RESUMO

OBJECTIVES: To define vitamin D levels and their association with cognition in subjects with exceptional longevity. DESIGN: Cross-sectional. SETTING: Community and long-term care facilities. PARTICIPANTS: Ashkenazi Jewish subjects (n = 253) with exceptional longevity, with comparison made to the Third National Health and Nutrition Examination Survey (NHANES III) participants aged 70 and older. MEASUREMENTS: Serum 25-hydroxyvitamin D levels were measured using liquid chromatography/tandem mass spectrometry analysis. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and clock drawing test (CDT: command and copy). RESULTS: The median age of the Ashkenazi subjects was 97 (interquartile range (IQR) 95-104). Age-associated rise in the prevalence of vitamin D insufficiency, defined as a serum vitamin D level of less than 30 ng/mL, was noted in NHANES III (P = .001). In the Ashkenazi group with longevity, the rate of vitamin D insufficiency was comparable with that of the NHANES III participants, who were up to 25 years younger. In the cohort with exceptional longevity, 49% demonstrated cognitive impairment as assessed according to MMSE score (impaired cognition, median 9.5 IQR 0-24); normal cognition, median 29 (IQR 18-30) P < .001). Vitamin D insufficiency was more prevalent in those with impaired cognition, defined according to the MMSE (71.8% vs 57.7%, P = .02) and the CDT copy (84.6% vs. 50.6%, P = .02), than in those with normal cognition. This association remained significant after multivariable adjustment in logistic regression models for cognitive assessments made using the MMSE (odds ratio (OR) = 3.2, 95% confidence interval (CI) = 1.1-9.29, P = .03) and the CDT copy (OR = 8.96, 95% CI = 1.08-74.69, P = .04). CONCLUSION: Higher vitamin D levels may be a marker of delayed aging, because they are associated with better cognitive function in people achieving exceptional longevity.


Assuntos
Transtornos Cognitivos/epidemiologia , Judeus , Longevidade , Deficiência de Vitamina D/epidemiologia , Vitamina D/análogos & derivados , Idoso , Biomarcadores/sangue , Cromatografia Líquida , Transtornos Cognitivos/etnologia , Estudos Transversais , Feminino , Humanos , Judeus/etnologia , Masculino , Pessoa de Meia-Idade , Inquéritos Nutricionais , Espectrometria de Massas em Tandem , Estados Unidos/epidemiologia , Vitamina D/sangue , Deficiência de Vitamina D/etnologia
16.
Community Dent Health ; 31(4): 212-8, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25665354

RESUMO

OBJECTIVES: Guided by the Andersen-Aday Behavioral Model of Health Care Utilization, this study compared primary dental care use trends between 2000 and 2010, and differences in primary dental care use between Israel's two largest ethnic groups, Jews and Arabs. METHODS: Two waves (years 2000 and 2010) of existing cross-sectional data collected from a nationwide sample on the population's health knowledge, attitudes and practice were used. This study uses the sample of Israeli-Jews (n = 2806) from 2000; and the nationally representative sample of Israeli-Jews (n = 2539) and Israeli-Arabs (n = 1723) from 2010. RESULTS: Primary dental care use increased between 2000 and 2010 in Israel. Israelis who had at least a high school diploma, average or higher income, no dental pain and reported flossing their teeth were more likely to use primary dental care, but this was true of fewer Israeli-Arabs than Israeli-Jews. Other variables, associated with use of primary dental care but differing by ethnic group, were: being older than 65 years, being a native-born Israeli, employment, and health risk factors such as smoking and obesity. CONCLUSIONS: As with other western societies and as indicated by the model's three factors (i.e., predisposing, enabling and reinforcing/need), disparities in primary dental care use were found based on income (i.e., enabling); immigrants and ethnic minority status (i.e., predisposing), and health risk such as smoking (i.e., reinforcing/need). It is evident that health promotion activities are needed to target specific population subgroups to reduce disparities in primary dental care utilisation.


Assuntos
Assistência Odontológica/estatística & dados numéricos , Atenção Primária à Saúde/estatística & dados numéricos , Adolescente , Adulto , Fatores Etários , Idoso , Árabes/etnologia , Índice de Massa Corporal , Estudos Transversais , Assistência Odontológica/tendências , Dispositivos para o Cuidado Bucal Domiciliar/estatística & dados numéricos , Escolaridade , Emigrantes e Imigrantes , Emprego/estatística & dados numéricos , Feminino , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Nível de Saúde , Humanos , Renda/estatística & dados numéricos , Israel/etnologia , Judeus/etnologia , Masculino , Estado Civil , Pessoa de Meia-Idade , Grupos Minoritários , Atenção Primária à Saúde/tendências , Fatores de Risco , Fumar , Escovação Dentária/estatística & dados numéricos , Adulto Jovem
17.
J Immigr Minor Health ; 16(5): 1007-10, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23584710

RESUMO

BRCA 1/BRCA2 founder mutations have been documented among Ashkenazi Jews. Little is known about cancer rates and cancer-related health behaviors among an insular subset of this population, Orthodox Jews. The goal of this study was estimate the risk of breast and ovarian among the Orthodox Jewish population. We used geo-coding with surveillance, epidemiology, and end results (SEER) data to identify this subgroup and estimate breast and ovarian cancer rates. Relative to neighborhoods with lower estimated Jewish populations, higher breast cancer rates were found in neighborhoods with higher estimated Orthodox Jewish population, there were no comparable differences in ovarian cancer rates. Implications include more research on health behaviors that may contribute to breast cancer in this insular community.


Assuntos
Neoplasias da Mama/epidemiologia , Judeus/estatística & dados numéricos , Neoplasias da Mama/etnologia , Feminino , Humanos , Incidência , Judeus/etnologia , Michigan/epidemiologia , Neoplasias Ovarianas/epidemiologia , Neoplasias Ovarianas/etnologia , Programa de SEER
18.
Parasitol Int ; 63(2): 456-62, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24201297

RESUMO

Intestinal parasites cause significant morbidity worldwide, particularly in developing populations. At least three pediatric populations reside in southern Israel: the Bedouin population, the general Jewish population and Jewish children of Ethiopian origin. Our aim was to compare intestinal parasite prevalence between the three pediatric populations in southern Israel. This is a retrospective, laboratory, population-based surveillance. Most ova and parasite (O&P) tests in southern Israel (hospital and community obtained) are performed by the hospital parasitology laboratory. All pediatric stool O&P tests examined by the hospital laboratory between 2007 and 2011 were included. Overall, 45,978 samples were examined; 27,354, 16,969 and 1655 from Bedouin, non-Ethiopian Jewish and Ethiopian children, respectively. 16,317 parasites were identified in 12,325 (26.8%) positive samples. Total prevalences were 36%, 11% and 46% for Bedouin, non-Ethiopian Jewish and Ethiopian children, respectively. Blastocystis hominis, Giardia lamblia and Entamoeba species were the most common parasites identified, constituting ≥80% of positive samples in all groups. Hymenolepis nana was rarely identified in non-Ethiopian Jewish children (0.04% of isolates compared with 2.6% and 0.5% in Bedouin and Ethiopian children, respectively). Other helminths, excluding H. nana and Enterobius vermicularis, were identified almost exclusively in Ethiopian children ≥5years of age. In conclusion, the Bedouin and Ethiopian children were characterized by higher parasite prevalence in stool, compared with the non-Ethiopian Jewish children, probably reflecting higher intestinal parasitic disease rates. Certain helminthic infections were identified almost exclusively in the Ethiopian children. These differences may be associated with lifestyle differences between the three populations.


Assuntos
Fezes/parasitologia , Doenças Parasitárias/etnologia , Doenças Parasitárias/epidemiologia , Árabes/etnologia , Criança , Etiópia/etnologia , Feminino , Humanos , Israel/epidemiologia , Judeus/etnologia , Masculino , Vigilância da População , Estudos Retrospectivos
19.
Int J Soc Psychiatry ; 60(6): 575-83, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24114530

RESUMO

BACKGROUND: Contrasting social status of ethnic groups differentially impacts the use of psychiatric services, including in Israel, despite its universal health system. However, relevant studies are limited. AIMS: To examine ethnic differences in mental health treatment gap and in access to specialized care. METHODS: Data were gathered from two sources. Study I included Mizrahi (Jews of North African/Asian origin, socially disadvantaged, n = 136) and Ashkenazi (Jews of European American origin, socially advantaged, n = 69) who were diagnosed with common mental disorders in the preceding 12 months in the Israeli component of the World Mental Health Survey. Study II included Mizrahi (n = 133) and Ashkenazi (n = 96) service users entering ambulatory mental health care. RESULTS: Study I showed that the treatment gap was larger among Mizrahi compared with Ashkenazi respondents (28% standard error (SE) = 4.1 and 45% SE = 6.2, respectively, sought services) following adjustment for sociodemographic confounders (adjusted odds ratio (AOR) = 2.28, 95% confidence interval (CI) = 1.1-4.8). Study II showed that the access to specialized care lagged over a year among 40% of service users of both ethnic groups. No significant ethnic differences emerged in variables related to delay in accessing care. CONCLUSIONS: Treatment gap was larger among ethnically disadvantaged compared with the advantaged group. However, once in treatment, service users of both ethnic groups report similar barriers to care.


Assuntos
Etnicidade/estatística & dados numéricos , Acesso aos Serviços de Saúde/estatística & dados numéricos , Disparidades em Assistência à Saúde/etnologia , Serviços de Saúde Mental/estatística & dados numéricos , Adulto , Feminino , Pesquisas sobre Atenção à Saúde , Disparidades em Assistência à Saúde/estatística & dados numéricos , Humanos , Israel/epidemiologia , Judeus/etnologia , Judeus/psicologia , Judeus/estatística & dados numéricos , Masculino , Transtornos Mentais/terapia
20.
Dynamis (Granada) ; 34(2): 377-401, 2014.
Artigo em Inglês | IBECS | ID: ibc-134734

RESUMO

This essay approaches the medieval Hebrew literature on women’s healthcare, with the aim of analysing notions and ideas regarding fertility, pregnancy and childbirth, as conveyed in the texts that form the corpus. Firstly, the work discusses the approach of written texts to pregnancy and childbirth as key elements in the explanation of women’s health and the functioning of the female body. In this regard it also explores the role of this approach in the creation of meanings for both the female body and sexual difference. Secondly, it examines female management of pregnancy and childbirth as recorded in Hebrew medical literature. It pays attention to both the attitudes expressed by the authors, translators and copyists regarding female practice, as well as to instances and remedies derived from "local" traditions -that is, from women's experience- in the management of pregnancy and childbirth, also recorded in the texts. Finally, the paper explores how medical theories alien to, or in opposition to, Judaism were adopted or not and, at times, adapted to Jewish notions with the aim of eliminating tensions from the text, on the one hand, and providing Jewish practitioners with adequate training to retain their Christian clientele, on the other (AU)


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Assuntos
Humanos , Feminino , Gravidez , Recém-Nascido , Parto/metabolismo , Parto/psicologia , Judeus/etnologia , Judeus/história , Caracteres Sexuais , Fertilidade/genética , Literatura Medieval/história , Parto/etnologia , Parto/fisiologia , Judeus/educação , Judeus/psicologia , Fertilidade/fisiologia
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